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目的探讨立体定向下多靶点毁损治疗先天性精神发育迟滞症的临床效果。方法在CT定位下,应用脑立体定向技术对12例先天性精神发育迟滞症病人进行颅内多靶点毁损治疗。按全国精神外科协作组织于1988年制定的评定方法、韦氏儿童智力量表(WISC)及简明精神病评定量表(BPRS)、社会功能量表(SFRS)、阳性症状量表(SAPS)进行疗效评定。结果12例患者术后随访,精神测评结果:恢复1例,显著进步8例,进步2例,无效1例;手术对智力无影响;BPRS、SAPS和SFRS总分较术前显著减低(P=0.000)。结论立体定向下多靶点毁损术是治疗先天性精神发育迟滞症的有效方法,有利于患儿提高生活自理和适应社会的能力。
Objective To investigate the clinical effect of stereotactic multi-target lesions in the treatment of congenital mental retardation. Methods CT stereotactic technique was used to treat 12 cases of congenital mental retardation in patients with intracranial multi-target lesion. The WISC and BPRS, SFRS and SAPS were evaluated according to the assessment method established by the National Association of Psychiatric Surgeons in 1988. assessment. Results 12 patients were followed up. The results of mental evaluation were as follows: 1 case recovered, 8 cases improved significantly, 2 cases improved and 1 case ineffective. The operation had no effect on intelligence. The total score of BPRS, SAPS and SFRS was significantly lower than that before operation (P = 0.000). Conclusion Stereotactic multi-target debridement is an effective method for the treatment of congenital mental retardation and is conducive to improve children’s ability to take care of themselves and adapt to society.