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目的:探讨中医验方清心滋肾汤辅助雌孕激素序贯治疗卵巢早衰临床效果。方法:研究对象选取杭州市中医院2014年3月—2015年3月收治的卵巢早衰患者120例,采用随机抽样方法分为对照组和中医组,各60例;其中对照组患者采用雌孕激素序贯治疗,中医组患者则在此基础上加用国医大师夏桂成中医验方清心滋肾汤辅助治疗;比较两组患者临床疗效,治疗前后Kupperman评分及血清激素水平等。结果:对照组和中医组患者治疗总有效率分别为60.00%,81.67%;中医组患者临床疗效优于对照组(P<0.05);中医组患者治疗后Kupperman评分显著优于治疗前和对照组(P<0.05);中医组患者治疗后卵泡刺激素(FSH),黄体生成激素(LH),血清雌二醇(E2)及抗苗勒氏管激素(AMH)水平明显优于治疗前和对照组(P<0.05)。结论:中医验方清心滋肾汤辅助西药治疗卵巢早衰可有效缓解临床症状体征,促进月经周期恢复,并有助于改善血清激素水平。
Objective: To investigate the clinical effect of TCM prescription Qingxinzishen Tang adjuvant estrogen and progestogen sequential therapy on premature ovarian failure. Methods: The subjects were selected from Hangzhou Hospital of Traditional Chinese Medicine from March 2014 to March 2015, 120 cases of premature ovarian failure were randomly divided into control group and TCM group, 60 cases each; the control group patients with estrogen and progesterone Sequential treatment, Chinese medicine group patients are based on the use of Chinese medicine master Xia Gui-cheng TCM prescription Qingxinzishen Tang adjuvant therapy; clinical efficacy of two groups were compared before and after treatment Kupperman score and serum hormone levels. Results: The total effective rates of the control group and the TCM group were 60.00% and 81.67% respectively. The clinical efficacy of the TCM group was better than that of the control group (P <0.05). The Kupperman score of the TCM group was significantly better than that before treatment and the control group (P <0.05). The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), serum estradiol (E2) and anti-Müllerian hormone (AMH) in the TCM group were significantly better than those before treatment and before treatment Group (P <0.05). Conclusion: TCM prescription Qingxinzishen Decoction can help alleviate symptoms and signs of early ovarian failure, promote the recovery of menstrual cycle and help to improve serum hormone levels.