Autoimmune diseases(AIDs)consist of a group of physiological disorders with highly diversified pathogenesis and clinical manifestations[1],which affect more than 5%of the population worldwide[2].So far,the etiology of the AIDs is still poorly understood,whereas it is generally believed that autoimmune disorder results from a complex interaction of genetic and epigenetic variations,as well as triggering environmental factors[3].Because of the varied phenotypes in different individuals of one AID and sometimes shared Of which group more than 5% of the population worldwide [2]. So far, the etiology of the AIDs is still poorly understood, it is generally believed that autoimmune disorder results from a complex interaction of genetic and epigenetic variations, as well as triggering environmental factors [3] .Because of the varied phenotypes in different individuals of one AID and sometimes shared