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目的了解医院重症监护病房(ICU)住院患者鲍曼不动杆菌医院感染情况及其耐药性,为临床合理预防和治疗鲍曼不动杆菌感染提供指导。方法采用回顾性调查方法,对江苏省某医院ICU住院鲍曼不动杆菌感染患者情况及其耐药性进行调查。结果从该医院ICU住院患者送检标本中共分离出63株鲍曼不动杆菌,分属63例患者的标本,含泛耐药菌株29例,占分离菌株的74.6%。有85.7%的鲍曼不动杆菌分离自痰液标本,主要感染部位为下呼吸道,其次是菌血症和泌尿道感染。所分离的鲍曼不动杆菌对复方新诺明和喹诺酮类抗菌药物耐药率较低,对头孢类抗菌药物和氨曲南耐药率均高于90%。结论该医院ICU鲍曼不动杆菌感染以下呼吸道感染和菌血症最为多见,多数送检样本中出现泛耐药鲍曼不动杆菌菌株,患者间存在交叉感染可能,临床合理选择抗菌药物治疗的同时需加强消毒工作。
Objective To understand the prevalence and drug resistance of Acinetobacter baumannii in hospital intensive care unit (ICU) in hospital and provide guidance for the clinical prevention and treatment of Acinetobacter baumannii infection. Methods A retrospective survey was conducted to investigate the prevalence and drug resistance of Acinetobacter baumannii inoculated in ICU of a hospital in Jiangsu Province. Results 63 strains of Acinetobacter baumannii were isolated from the inpatients of ICU in our hospital, belonging to 63 patients. There were 29 cases of pan-resistant strains, accounting for 74.6% of isolates. 85.7% of Acinetobacter baumannii isolated from sputum specimens, the main site of infection for the lower respiratory tract, followed by bacteremia and urinary tract infections. Acinetobacter baumannii isolates showed low resistance rates to cotrimoxazole and quinolone antibacterials, and the rates of resistance to cefpimetics and aztreonam were all higher than 90%. Conclusions Acinetobacter baumannii ICU in the hospital is the most common respiratory tract infection and bacteremia. Most pan-drug-resistant Acinetobacter baumannii isolates are present in this hospital, and there is a possibility of cross-infection among patients. Clinically, antibiotics therapy At the same time need to strengthen disinfection work.