用二亚硝基哌嗪诱发大鼠鼻咽癌,观察了癌变过程中各级病变的酶活性变化。乳酸脱氢酶活性从增生、化生阶段到癌前和癌变整个过程呈逐步增高;琥珀酸脱氢酶活性处于一种低水平波动,变化不显著;非特异性酯酶在增生、化生阶段活性显著增高,但到癌前和癌变阶段则明显减弱,甚至消失,变化最大,在各级病变中反应最敏感。 The nitrosopiperazine was used to induce nasopharyngeal carcinoma in rats, and the changes of the enzyme activities of lesions at all stages were observed. Lactate dehydrogenase activity increased gradually from hyperplasia and metaplastic stage to pre-cancerous stage and carcinogenesis. Succinic acid dehydrogenase activity was in a low level and the change was insignificant. The activity of non-specific esterase in proliferation and metaplasia Significantly increased, but to pre-cancerous and cancerous stage was significantly weakened, or even disappear, the greatest change in all levels of disease response the most sensitive.