目的:探讨软镜下不同钬激光连续激发时间对肾内碎石效果的影响。方法:选取2014年3月至2018年6月在本院治疗的180例肾结石患者，按钬激光连续激发时间不同分为5 s的A组、10 s的B组和15 s的C组，各60例。软镜下采用钬激光方法进行碎石，通过比较三组的一次性结石清除率、并发症、手术时间、结石排净时间、术中出血量、住院时间来评价三种手术方法的临床疗效。结果:B组的一次性结石清除率[100%(60/60)]高于A组[90%(54/60)]和C组[95%(57/60)]，B组的并发症发生率[0%(0/60)]明显低于A组[6.67%(4/60)]和C组[13.33%(8/60)]，三组比较差异均有统计学意义(n P<0.05)；术中出血量和住院时比较，B组小于A、C组，A组小于C组，差异均有统计学意义(n P<0.05)；手术时间和结石排净时间比较，C组小于A、B组，B组小于A组，差异均有统计学意义(n P<0.05)。n 结论:肾内结石的患者采用连续激发10 s，间歇5 s的钬激光治疗方案的一次性结石清除率高，并发症最少，术中出血量少，患者的住院时间减少，患者的治疗成本降低，值得临床推广。“,”Objective:To investigate the effect of continuous excitation time of different holmium laser under soft mirror on intrarenal lithotripsy.Methods:From March 2014 to June 2018, 180 cases of renal calculi treated in our hospital were divided into group A(60 cases, 5 s), group B(60 cases, 10 s) and group C(60 cases, 15 s) according to the duration of continuous holmium laser excitation. The clinical effects of the three surgical methods were evaluated in terms of clearance rate of disposable lithotripsy, complications, operation time, stone clearance time, intraoperative bleeding volume and hospitalization time.Results:The stone clearance rate of group B was 100% higher than that of group A and group C(90% and 95%). The complication rate of group B was 0% lower than that of group A and group C(6.67% and 13.33%). There was significant difference among the three groups(n P<0.05). There were significant differences in intraoperative bleeding volume between group B