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作者报道旧金山加州大学放射肿瘤科1956～1990年收治的鼻咽癌(NPC)252例。选择一组经免疫组化检查、资料完整的30例,男21例,女9例,中位年龄50岁(10～74岁)。症状和随访中位时间分别为7个月(1～37个月)和44个月(3～288个月),局部区域复发和远处转移中位时间分别为11.5个月(0～85个月)和3个月(1～148个月)。根据WHO分类:NPC分为鳞状细胞癌(WHO Ⅰ型)、非角化细胞癌(WHO Ⅱ型)和未分化癌(WHO Ⅲ型)。肿瘤组织切片用苏木精和曙红染色,对第Ⅷ因子相关抗原用标准的免疫过氧化物酶染色技术使血管内皮细胞染色,清楚地显示肿瘤微血管。28例微血管染色满意,2例因微血管染色少不能评价。光镜下以40×和100×测定每个区域最丰富的毛细血管和小静脉密度。这些新生毛细血管“热点”可出现在癌灶的任一区域,常见于癌细胞群周围。一些内皮细胞或其细胞群对第Ⅷ因子相关抗原染色阳性,与邻近细胞群有显著区别呈单一可数的微血管。据研究确定微血管<60/200
The authors report 252 cases of nasopharyngeal carcinoma (NPC) admitted to the Department of Radiation Oncology, University of California, San Francisco from 1956 to 1990. Select a group of immunohistochemical examination, complete data 30 cases, 21 males and 9 females, the median age of 50 years (10 to 74 years old). The median time to symptoms and follow-up were 7 months (range, 1 to 37 months) and 44 months (range, 3 to 288 months), respectively. The median regional recurrence and distant metastases time were 11.5 months Month) and 3 months (1 to 148 months). According to WHO classification: NPC is divided into squamous cell carcinoma (WHO Ⅰ), non-keratinocyte carcinoma (WHO Ⅱ) and undifferentiated carcinoma (WHO Ⅲ). Tumor tissue sections were stained with hematoxylin and eosin, staining for endothelial cells with standard immunoperoxidase staining for factor Ⅷ-related antigens, and clearly showing tumor microvessels. 28 cases of microvascular staining satisfactory, 2 cases can not be evaluated due to microvascular staining. Light microscopy to 40 × and 100 × determination of each region the most abundant capillary and venule density. These nascent capillaries “hot spots” can appear in any area of the foci, commonly found around cancer cell populations. Some endothelial cells or their cell populations stained positive for factor Ⅷ related antigens, with a significant difference between adjacent cell populations was a single countable number of microvessels. According to the study to determine microvascular <60/200