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肿瘤干细胞是指存在于肿瘤组织中的具有干细胞特性,即能够多向分化和自我更新的一类细胞群。随着肿瘤干细胞概念的提出,乳腺癌干细胞成为当今科研领域的一个研究热点。因此,了解如何分选乳腺癌干细胞及如何维持其“干性”对治疗及预防乳腺癌具有至关重要的意义。主要从乳腺癌干细胞分选、相关信号通路、上皮-间充质转换(EMT)等方面进行综述。
Tumor stem cells refer to a group of cells that have stem cell characteristics that exist in tumor tissue, ie, are capable of multidirectional differentiation and self-renewal. With the introduction of the concept of cancer stem cells, breast cancer stem cells become a research hotspot in the field of scientific research today. Therefore, understanding how to sort breast cancer stem cells and how to maintain their “dryness” is of crucial importance for the treatment and prevention of breast cancer. Mainly from the breast cancer stem cell sorting, related signaling pathways, epithelial-mesenchymal transition (EMT) and other aspects are reviewed.