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LH/FSH释放激素具有显著的诊断和治疗作用,因而引起了重视。作者研究了37例继发闭经患者,给她们静注LH-RH25微克,于注射前及注射后的不同时间内分别采血,用双抗体放射免疫法测定血浆LH、FSH和TSH。对LH-RH的反应:LH是以给药后25分钟和45分钟时LH的平均值,与给药前基础水平之差来表示,FSH则以给药后40分钟和60分钟时FSH的平均值与给药前基础水平之差来表示。作者发现,在卵巢早萎闭经中:3例更年期综合症患者的基础水平均较高(FSH14.7±1.5微克/毫升,LH8.4±1.0微克/毫升),对LH-RH的反应明显(LH13.4±1.4微克/毫升P<0.05,FSH5.7±0.02微克/毫升P<0.001)。雌激素水平极低。其中2例卵巢活检显示萎缩无始基滤泡。在多囊卵
LH / FSH release hormone has a significant diagnostic and therapeutic effect, and thus attracted the attention. The authors studied 37 patients with secondary amenorrhea and received intravenous LH-RH of 25 μg. Blood samples were collected before injection and at different times after injection. Plasma LH, FSH and TSH were measured by double antibody radioimmunoassay. Response to LH-RH: LH was calculated as the difference between the mean LH at 25 and 45 minutes after administration and the baseline level before administration, and the mean FSH at 40 and 60 minutes after FSH administration The difference between the value and the basal level before administration indicates. The authors found that in the premenopausal ovarian amenorrhoea: 3 patients with climacteric syndrome had higher basal levels (FSH 14.7 ± 1.5 μg / ml, LH 8.4 ± 1.0 μg / ml) and a clear response to LH-RH ( LH13.4 ± 1.4 μg / ml P <0.05, FSH 5.7 ± 0.02 μg / ml P <0.001). Estrogen levels are very low. Two cases of ovarian biopsy showed no shrinkage of primordial follicles. In polycystic eggs