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目的:探讨采用低能量饮食减重对慢性肾脏病肥胖患者的影响。方法:以“慢性肾脏病(chronic kidney disease)、肥胖(obesity)、减重(weight loss)、低能量饮食(low caloric diet)”为检索词检索Medline、EMBase、Pub Med数据库、中国生物医学文献数据库、万方数据库,收集慢性肾脏病肥胖患者减重干预的随机对照试验或自身前后对照试验,筛选、评价文献并提取数据进行Meta分析。结果:共纳入3项研究,共51例患者。Meta分析结果表明,体重下降能够减少慢性肾脏病肥胖患者的蛋白尿[SMD=0.87,95%CI(0.46,1.28)]。结论:低能量饮食减重干预有利于改善慢性肾脏病肥胖患者的尿蛋白排泄。
Objective: To investigate the effects of diet with low energy on obese patients with chronic kidney disease. METHODS: Medline, EMBase, Pub Med databases were searched using the term “chronic kidney disease, obesity, weight loss, low caloric diet” Medical literature database, Wanfang database, randomized controlled trials to collect weight loss intervention in patients with chronic kidney disease obesity or their own before and after the control test, screening, evaluation of literature and data extraction Meta analysis. Results: A total of three studies were enrolled, 51 patients in total. Meta-analysis showed that weight loss reduced proteinuria in obese patients with chronic kidney disease [SMD = 0.87, 95% CI (0.46, 1.28)]. Conclusion: The diet intervention with low energy diet is beneficial to improve urinary protein excretion in obese patients with chronic kidney disease.