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目的:探讨新辅助化疗与营养支持综合治疗对老年结肠癌患者血清肿瘤标记物水平、COX-2及生活质量影响及临床意义。方法:选取我科收治的老年结肠癌患者80例,根据治疗方案不同分为对照组与试验组。对照组常规行结肠癌根治切除术,试验组应用FOLFOX3方案。比较两组患者血清肿瘤标记物CEA及CA19-9水平、COX-2水平及CD4~+、CD8~+及tM2-PK水平。结果:与治疗前相比,治疗后试验组和对照组CEA及CA19-9水平降低(P<0.05),COX-2、tM2-PK水平降低(P<0.05),CD4~+及CD4~+/CD8~+水平降低(P<0.05),CD8~+水平升高(P<0.05)。与对照组比较,试验组COX-2、tM2-PK水平、CD4~+、CD8~+水平改善明显优于对照组,差异具有统计学意义(P<0.05),而CEA及CA19-9水平组间比较,差异无统计学意义(P>0.05)。结论:新辅助化疗与营养支持综合治疗可杀伤老年结肠癌患者全身不可见转移肿瘤细胞,控制病情,临床疗效理想。
Objective: To investigate the effect of neoadjuvant chemotherapy and nutritional support on serum tumor markers, COX-2 and quality of life in elderly patients with colorectal cancer and its clinical significance. Methods: 80 cases of elderly patients with colon cancer selected from our department were divided into control group and experimental group according to different treatment options. Control group conventional colon cancer radical resection, test group application FOLFOX3 program. Serum tumor markers CEA and CA19-9 levels, COX-2 levels and CD4 ~ +, CD8 ~ + and tM2-PK levels were compared between the two groups. Results: Compared with those before treatment, the levels of CEA and CA19-9 in the experimental group and the control group decreased (P <0.05), the levels of COX-2 and tM2-PK decreased (P <0.05) / CD8 + levels (P <0.05) and CD8 + levels (P <0.05). Compared with the control group, the levels of COX-2, tM2-PK, CD4 ~ + and CD8 ~ + in the experimental group were significantly better than those in the control group (P <0.05), while those in the CEA and CA19-9 groups Between the two groups, the difference was not statistically significant (P> 0.05). Conclusion: Neoadjuvant chemotherapy and nutritional support can kill the elderly patients with colon cancer invisible metastasis of tumor cells, control the disease, the clinical efficacy of the ideal.