裂殖子表面抗原ＭＳＡ 1和ＭＳＡ 2是编码裂殖子表面抗原的多基因家簇 ,有大量的保守区和可变区。这个基因被认为与恶性疟原虫的入侵 ,保护性免疫和免疫逃避有关。研究表明该基因在高疟区、低疟区及在不同的疟疾季节性传播中表现出多态性[1-3 ] 。为了解在云南不同疟疾流行区的 Merozoite surface antigens MSA 1 and MSA 2 are multigene clusters encoding merozoite surface antigens with a large number of conserved and variable regions. This gene is thought to be involved in the invasion of P. falciparum, protective immunity and immune evasion. Studies have shown that the gene shows polymorphism in the high malaria area, the low malaria area and in the seasonal spread of different malaria [1-3]. To understand the different malaria endemic areas in Yunnan