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目的观察硫辛酸注射液联合丹红注射液治疗有机磷农药中毒发生周围神经损害的疗效。方法将132例患者分成治疗组(硫辛酸注射液联合丹红注射液静脉滴注)和对照组(采用VitB1 100mg肌注+国产甲钴胺1 000μg入液静点)。比较临床症状体征,运动神经传导速度(MCV),感觉神经传导速度(SCV)变化。结果观察组总有效率为80.6%,对照组总有效率为56.7%,两组差异有统计学意义(P<0.05)。两组治疗前后MCV、SCV的差异有统计学意义(P<0.01)。结论硫辛酸注射液联合丹红注射液可以明显改善临床症状,提高周围神经传导速度,有延缓神经损伤发展的作用。
Objective To observe the efficacy of lipoic acid injection combined with Danhong injection in the treatment of peripheral nerve damage caused by organophosphorus pesticide poisoning. Methods 132 patients were divided into treatment group (lipoic acid injection combined with Danhong injection intravenous drip) and control group (VitB1 100mg intramuscular injection of homemade mecobalamin 1 000μg into the liquid static point). The changes of clinical symptoms and signs, motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) were compared. Results The total effective rate was 80.6% in the observation group and 56.7% in the control group, with significant difference between the two groups (P <0.05). The difference of MCV and SCV between the two groups before and after treatment was statistically significant (P <0.01). Conclusion Lipoic acid injection combined with Danhong injection can significantly improve clinical symptoms, improve peripheral nerve conduction velocity, delay the development of nerve injury.