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目的 探讨巯基物质在急性坏死性胰腺炎(ANP)时对肺泡细胞的保护作用。方法将108只大鼠随机分为A组(生理盐水组)、B组(巯基物质处理组)、C组(假手术组)。检测各组大鼠胰腺组织内巯基、丙二醛含量;观察光镜下胰腺组织、电镜下肺组织形态学改变。结果B组胰腺组织巯基含量明显低于C组,高于A组。B组胰腺组织丙二醛含量均明显高于C组,低于A组。B组胰腺组织及肺组织病理改变较A组减轻,腹水量亦少于A组。结论 ANP时巯基物质减少,丙二醛含量增加明显;外源性巯基物质可作为氧自由基清除剂保护胰腺细胞,同时保护肺泡细胞。
Objective To investigate the protective effect of sulfhydryl on alveolar cells in acute necrotizing pancreatitis (ANP). Methods 108 rats were randomly divided into group A (saline group), group B (sulfhydryl group) and group C (sham group). The contents of sulfhydryl and malondialdehyde in pancreas of rats in each group were measured. The morphological changes of lung tissue were observed under light microscope. Results The content of thiol in pancreatic tissue in group B was significantly lower than that in group C and higher than that in group A. The content of malondialdehyde in pancreas of group B was significantly higher than that of group C, lower than that of group A. The pathological changes in pancreas and lung in group B were less than those in group A, and the amount of ascites was less than that in group A. Conclusions The sulfhydryl groups decrease and MDA content increase obviously in ANP. Exogenous thiols can protect pancreatic cells as oxygen free radical scavenger and protect alveolar cells.