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目的探讨育龄妇女自身免疫抗体及生殖道衣原体(CT)、支原体(UU)感染与不育不孕患者的关系。方法选择2007年来我院门诊就诊和妇科住院的自然流产患者、不孕患者,没有反复流产史,且有一个健康婴儿的健康体检者,分别检测封闭抗体(APLA)、抗精子抗体(AsAb)、抗子宫内膜抗体(EMAb)、抗心磷脂抗体(ACA)解脲支原体(UU)和沙眼衣原体(CT)。结果自然流产患者中APLA阴性占75%,不孕患者APLA阴性占17.73%,对照组APLA阴性占8.14%;流产组、不孕组的APLA、AsAb、EMAb、ACA、UU、CT阳性检出率明显高于对照组。结论育龄妇女体内存在APLA、AsAb、ACA、EMAb及生殖道支原体或衣原体感染与不育不孕患者密切相关,对有不良孕产史及不孕的患者进行自身免疫抗体及生殖道衣原体、支原体的检测,可为诊断及治疗提供科学的依据。
Objective To investigate the relationship between autoimmune antibodies and genital chlamydia (CT) and mycoplasma (UU) infection in infertile women and infertility infertility patients. Methods The patients with spontaneous abortion, infertility, gynecological hospitalizations and outpatients admitted to our hospital in 2007 and no history of repeated abortion were enrolled in the study. A healthy baby with healthy abortion was tested for APLA, AsAb, Anti-endometrial antibody (EMAb), anti-cardiolipin antibody (ACA) Ureaplasma urealyticum (UU), and Chlamydia trachomatis (CT). Results The APLA negative rate was 75% in spontaneous abortion patients, 17.73% in infertile patients, and 8.14% in control patients. The positive rates of APLA, AsAb, EMAb, ACA, UU and CT in abortion group and infertility group Obviously higher than the control group. Conclusions There is a close relationship between APLA, AsAb, ACA, EMAb and genital Mycoplasma or Chlamydia infection in infertile women and infertility infertility patients. In patients with poor pregnancy history and infertility, autoimmune antibodies and genital Chlamydia, Mycoplasma Detection, diagnosis and treatment can provide a scientific basis.