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近几年来,根据肿瘤细胞增殖动力学的理论,指导临床实践,使肿瘤化学治疗的疗效不断提高,过去被认为难于治愈的绒毛膜上皮癌、白血病,经过化学药物治疗,有不少已存活五年以上,有的被认为已经治愈。但是,对多数恶性肿瘤尤其是鼻咽癌,至今还被认为单独应用化学药物治疗只能使病情缓解,生命延长,而不能根治。我院自1964年7月～1968年8月使用阻断下半身血循环,上半身静脉注射氮芥(简称半身化疗)治疗鼻咽部恶性肿瘤1,180例。其中423例经半身化疗后再加放射治疗;其余757例仅用半身化疗,部分病例加用了其他抗癌药物如环磷酰胺、噻替派、氧化氮芥,其中有5例(0.66%)已存活五年以上,现将此5例摘要报告如下:
In recent years, according to the theory of tumor cell proliferation kinetics, guided clinical practice, the therapeutic efficacy of cancer chemotherapy has been continuously improved. Many chorionic epithelial cancers and leukemias that were considered to be difficult to cure have undergone chemical drug treatment and many have survived. Over the years, some are considered cured. However, for most malignant tumors, especially nasopharyngeal cancer, it is still considered that the use of chemical drugs alone can only relieve the disease, prolong life, and can not be cured. In our hospital from July 1964 to August 1968, we used blood circulation to block the lower body, and intravenous nitrogen mustard (half-body chemotherapy) was used to treat 1,180 cases of nasopharyngeal malignancies. Of these, 423 were treated with radiotherapy after hemi-radiotherapy; half of the remaining 757 were treated with only half-body chemotherapy, and some other cases were treated with other anti-cancer drugs such as cyclophosphamide, thiotepa, and nitric oxide mustard, of which 5 cases (0.66%). Has survived for more than five years, now summarizes the five cases as follows: