在筛选合适鼻粘膜促进剂的过程中 ,经常发现有毒性存在。磷脂类衍生物作为体内磷脂的代谢产物 ,因其低毒性而成为促进鼻粘膜吸收的研究热点之一。本文对磷脂类衍生物的结构、应用及毒性等进行综述 ,并对其发展前景进行了展望 Toxicity is often found during the screening of suitable nasal mucosal stimulants. Phospholipid derivatives, as the metabolites of phospholipids in vivo, have become one of the research hotspots to promote nasal mucosa absorption because of their low toxicity. In this paper, the structure, application and toxicity of phospholipid derivatives were reviewed and the prospects of their development were prospected