镇痛镇静治疗已经成为重症监护室(Intensive care unit,ICU)的常规治疗之一,主要目标是缓解疼痛及不适,抗焦虑,便于机械通气,改善睡眠质量,使危重患者容易觉醒,并且配合治疗,但由此出现的并发症也造成了机械通气时间的延长、住院日期延长等。集束化干预则是按照循证医学和临床实践的结果所建立起来的共同遵守的医疗行为规范。本文综述了镇痛镇静集束化干预策略的实施方法以及在临床过程中存在的问题。 Analgesic sedation has become one of the routine treatments for intensive care units (ICU). Its main goals are to relieve pain and discomfort, to relieve anxiety, to facilitate mechanical ventilation, to improve sleep quality, to make critically ill patients awake easily and to cooperate with treatment , But the resulting complications also contributed to the extension of mechanical ventilation, hospitalization dates and so on. Aggregate intervention is a commonly observed code of medical conduct that has been established as a result of evidence-based medicine and clinical practice. This article reviews the implementation of the sedation and bolting interventional strategies for analgesia and the problems that exist in clinical practice.