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高丽参口服液急性毒性实验,小鼠经灌胃给药最大耐受量为30g/kg体重,腹腔注射给药的LD50为(129±1.5)g/kg体重,大鼠长期毒性实验分别灌胃给药4.0g/kg、2.0g/kg和1.0g/kg体重,对照组给予等容积蒸馏水,连续4周,各组无动物死亡,各项指标检查正常,病理报告高剂量组有3只动物部分肝细胞胞浆疏松化和气球样变性,中、低剂量组无明显改变,高剂量组存活动物于停药10d后,病理检查正常.
The acute toxicity test of ginseng oral solution showed that the maximum tolerated dose of mice was 30g / kg body weight by intragastric administration and the LD50 was (129 ± 1.5) g / kg body weight by intraperitoneal injection. Long-term toxicity test Gavage administration of 4.0g / kg, 2.0g / kg and 1.0g / kg body weight, the control group was given an equal volume of distilled water for 4 weeks, no animals died in each group, the indicators were normal, high-dose Group of three animals, part of the loosening of cytoplasm of hepatocytes and balloon-like degeneration, no change in medium and low dose groups, high-dose group of surviving animals 10d after withdrawal, the pathological examination was normal.