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报告237例苯妥英钠过量的神经系统毒性反应。发现药物剂量越大,毒性反应出现的时间越早。毒性反应的临床表现以小脑功能障碍最多见。其次为意识障碍和植物神经功能紊乱症状。毒性反应经及时治疗,大多能恢复。5例急性中毒的患者治愈后再次服苯妥英钠有毒性反应的再发,故毒性反应经治疗恢复后,以改服其他抗癫痫药为宜。
Reported 237 cases of phenytoin excess neurotoxic reaction. The greater the dose of drug found, the earlier the toxic reaction occurred. The clinical manifestations of toxic reactions are the most common cerebellar dysfunction. Followed by disturbance of consciousness and autonomic dysfunction. Toxic reactions by timely treatment, most can be restored. 5 cases of acute poisoning patients treated with phenytoin sodium again after the reoccurrence of toxic reactions, so after the recovery of toxic reactions to change clothes for other antiepileptic drugs is appropriate.