The Preparation and Biocompatibility Study on Fe2O3 Magnetic Nanoparticles Used in Tumor Hyperthermi

来源 :中国生物医学工程学报(英文版) | 被引量 : 0次 | 上传用户:Mickey123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective:To evaluate the in vitro and in vivo toxicity of self-prepared nanosized Fe2 O3, which has the potential implication in tumor hyperthermia. Methods:Fe2O3 nanoparticles were prepared by improving co-precipitation, which characterization was detected by TEM, XRD, CMIAS, EDS. MTT assay was used to evaluate the in vitro cytotoxicity test; hemolytic test was carried out to estimate whether it has blood toxicity;Fe2O3 suspended in sterile 0.9% NaCl was intraperitoneally injected into Kunming mouse to calculate the LD50; micronucleus (MN) were reckoned to identify whether it is genotoxic. Results :The nanoparticles are brown spherical particles with diameter ranging from 8 to 15 nm, which have good decentralization and stability. The experiments also showed that the toxicity of the material on mouse fibroblast (L-929) cell lines was 0 - 1 degree; it has no hemolysis activity; LD50 arrived at 5.45 g/kg-1 after intraperitoneal injection of 1 ml suspension; micronucleus test showed that it has no genotoxic effects either. Conclusion:The results showed that the Fe2O3 nanoparticles are prepared successfully, the self-prepared nanosized Fe2O3 is a kind of high biocompatibility materials and perhaps it is suitable for further application in tumor hyperthermia.
其他文献
南水北调工程是缓解我国北方地区水资源危机的一项战略性工程,工程投资大、战线长、施工环境复杂,安全隐患多。工程的安全生产管理是一个项目能否正常进行的关键所在,它不仅关系
目的探讨先天性心脏病介入治疗的临床疗效。方法回顾分析该院2003年6月 ̄2005年4月连续施行的先天性心脏病介入治疗285例,其中动脉导管未闭(PDA)封堵术87例,房间隔缺损(ASD)封
目的 探讨前牙切角缺损一次性美容修复的效果.方法 局麻下植入自攻自断螺纹钉固位,用光固化树脂一次性分层光照修复.结果 8年来临床应用126例,随访观察成功116例,失败10例,成
OBJECTIVE To decrease radiation injury of the esophagus and lungs by utilizing a CT scan in combination with PET tumor imaging in order to minimize the clinical
目的:以马德里某自治社区(ACT)里的移民结核病人为研究对象,确定与总诊断延误(TDD)、病人延误(PD)以及卫生服务机构延误(HSD)有关的诸因素.研究方法:对2003年ACT内15家医院诊
20世纪90年代,无论发达国家还是发展中国家,金融危机频繁爆发,致使各国政府不得不采取各种应急措施消除危机带来的冲击,尤其是1997年爆发的东南亚金融危机,使亚洲各国乃至整
目的:观察明目熏洗液熏洗治疗慢性结膜炎的临床疗效.方法:观察组患者40例80眼,采用明目熏洗液熏洗治疗;对照组32例64眼予以0.25%氯霉素滴眼液滴眼,对2组的治疗结果进行对比分
结合本单位工作形势和问题为切入点,以激励、支持和制度三要素为突破口,分析并探讨充分调动医学科技人员积极性和创造性的有效管理措施.
建筑技术的发展让建筑立面变得更加的活跃和自由,而以前许多不引人注意的构件也逐渐走到了前排,甚至成为建筑的至关重要的因素,而建筑表皮已经成为一种既定的概念而深入人心.
目的 探讨应用简易X线定位方法对乳腺隐匿性病灶切除的应用价值.方法 在普通钼靶乳腺机上应用简易X线定位法,对31例乳腺隐匿性可疑病变进行病灶切除术前定位.结果 30例一次定