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目的:探讨艾菲提蒙汤对实验性动脉粥样硬化(AS)家兔血脂及主动脉病理结构的影响。方法:50只健康家兔,取空白组8只给予基础饲料,42只给予高脂饲料喂养60天建立AS家兔模型,取40只模型动物随机分为模型组,阳性药组(辛伐他汀),艾菲提蒙汤低、中、高剂量组,各组家兔分别灌胃给药,连续6周,测定兔血清中TC、TG、HDL-C、LDL-C含量,并观察各组动物主动脉病理形态学变化。结果:艾菲提蒙汤各剂量组可明显降低兔血清中TG、TC、LDL-C含量,与模型组比较差异具有统计学意义(P<0.05~0.01),艾菲提蒙汤可明显改善模型动物主动脉病理形态结构。结论:艾菲提蒙汤对实验性AS家兔模型有明显的治疗作用。
Objective: To investigate the effect of Efitiutang Decoction on blood lipid and pathological structure of aorta in rabbits with experimental atherosclerosis (AS). Methods: Fifty healthy rabbits were randomly divided into model group and control group (simvastatin group, n = 8). Eighty rabbits in blank group were fed with basal diet and 42 were fed with high fat diet for 60 days. ), Afetifentang Decoction low, medium and high dose group, each group of rabbits were intragastrically administered for 6 weeks, the determination of serum levels of TC, TG, HDL-C, LDL-C in rabbits, and observed in each group Pathological changes of animal aorta. Results: All the doses of Efitiutang decoction could significantly reduce the contents of TG, TC and LDL-C in rabbit serum, and there was significant difference compared with the model group (P <0.05 ~ 0.01) Model animal aorta pathology morphology structure. Conclusion: Efitiutang decoction has obvious curative effect on experimental AS rabbit model.