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目的探讨当归补血汤对肿瘤生长的抑制作用。方法先造模,肿瘤细胞悬液接种于小鼠右前腋下,体内传代两次后接种于正式实验小鼠上,用当归补血汤(DBD)高、低剂量和西药环磷酰胺(CTX)分组进行灌胃和腹腔注射,20天后取材称瘤重、测脾脏胸腺重量指数、计数肿瘤肺转移灶个数、眼球摘除取血测量小鼠血清中粒细胞-巨噬细胞集落刺激因子(GM-CSF)的含量来初步观察本方对Lewis肺癌肿瘤生长的抑制作用。结果当归补血汤能够显著抑制肿瘤的肺转移、脾脏胸腺指数显著升高、GM-CSF含量显著升高,在这三个方面中药组与CTX比较上均有统计学意义。结论当归补血汤能够显著抑制Lewis肺癌小鼠肿瘤的转移,并能显著提高肿瘤小鼠的免疫功能。
Objective To investigate the inhibitory effect of Danggui Buxue Tang on tumor growth. Methods The tumor cells were inoculated into the right anterior arches of the right anterior chamber of the mice and inoculated twice daily in vivo. The experimental mice were inoculated with high and low doses of DBD and CTX, Gavage and intraperitoneal injection, 20 days after the material was weighed, measured thymus weight index of spleen, count the number of lung metastases, enucleation of blood in mice serum granulocyte-macrophage colony stimulating factor (GM-CSF ) Content to initially observe the side of Lewis lung cancer tumor growth inhibition. Results Dangguibuxuetang can significantly inhibit the lung metastasis of the tumor, the spleen thymus index was significantly increased, GM-CSF content was significantly increased in these three aspects compared with the CTX CTX were statistically significant. Conclusion Danggui Buxue Decoction can significantly inhibit the tumor metastasis in Lewis lung cancer mice and can significantly improve the immune function of tumor mice.