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子宫内膜异位的病人,子宫内膜的PGF_(2α)和PGE_2的水平升高。这样,PG_s可能与子宫内膜异位的症状有关。因此,作者用安慰剂对照双盲实验去评价PG抑制剂对宫内膜异位的治疗作用。在18名妇女中13人经腹腔镜检查,5人经盆腔探查术诊断有子宫内膜异位。平均33.3岁,平均产次是1.4,患子宫内膜异位症平均7.7年。分别给予安慰剂(1×3),乙酰水杨酸(0.5g×3),消炎痛(25mg×3)和Tolfenamic acid(200mg×3),在连续两个月经周期期间,于周期的第二十天至经期末,按随机顺序口服给药。用特异的记分法来评价宫内膜异位症状的严重程度。要求病人记录(1)疼的症状(盆腔部疼、下背疼、走路疼、性交疼、排便疼、头疼);(2)胃肠道症状(恶心、呕吐、腹泻);(3)精神症状(失眠、精神不安)。在试
In patients with endometriosis, endometrial levels of PGF_ (2α) and PGE_2 are elevated. Thus, PG_s may be related to the symptoms of endometriosis. Therefore, the authors used placebo-controlled double-blind experiments to evaluate the therapeutic effect of PG inhibitors on endometriosis. Thirteen of 18 women underwent laparoscopy and five were diagnosed with endometriosis by pelvic exploration. Average 33.3 years old, the average birth time was 1.4, with an average of 7.7 years of endometriosis. Placebo (1 × 3), acetylsalicylic acid (0.5g × 3), indomethacin (25mg × 3), and Tolfenamic acid (200mg × 3) were administered respectively during the second menstrual cycle Ten days to the end of the menstrual period, oral administration in random order. Specific scoring method to evaluate the severity of endometriosis. Patients are required to record (1) symptoms of pain (pelvic pain, lower back pain, walking pain, painful intercourse, defecation pain, headache); (2) gastrointestinal symptoms (nausea, vomiting, diarrhea); (Insomnia, nervousness). In the test