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目的观察MOAP方案治疗急性淋巴细胞白血病(ALL)的近期疗效和不良反应。方法我科于2003年1月-2008年12月应用MOAP方案治疗30例ALL,对照组用TOLP方案,2个疗程评价化疗方案的疗效,同时记录不良反应。结果MOAP组治疗初治ALL缓解率90.9%,对照组86.2%。MOAP组达到缓解的时间(15.7±6.4)d,对照组(19.8±3.2)d。MOAP组感染率、药物不良反应均低于对照组。结论MOAP方案治疗ALL有良好的疗效,且耐受性好。
Objective To observe the short-term efficacy and side effects of MOAP regimen in the treatment of acute lymphoblastic leukemia (ALL). Methods From January 2003 to December 2008, 30 cases of ALL were treated with MOAP regimen. The control group was treated with TOLP regimen. Two courses of chemotherapy were used to evaluate the efficacy of the regimen and the adverse reactions were recorded. Results The rate of initial response to ALL in the MOAP group was 90.9% and that in the control group was 86.2%. MOAP group reached remission time (15.7 ± 6.4) d, control group (19.8 ± 3.2) d. MOAP group infection rate, adverse drug reactions were lower than the control group. Conclusion MOAP treatment of ALL has a good effect, and well tolerated.