近年,心血管新药不断出现,临床上为了提高疗效,广泛联合用药而导致不良反应大大增加,甚至中毒死亡。这种药物的不良反应是通过药物相互作用,改变了作用部位的药物浓度,或通过药物受体敏感性的改变而产生的。心血管药物相互作用的重要性是由心脏病对人体危害的严重性以及许多心血管药治疗浓度范围狭窄决定的。通过相互作用,往往使原来有效的剂量变成亚治疗量或中毒量而危害生命。如上所述,心血管药物相互作用的后果十分严重,但仍未为人们充分认识,这是因为药物的毒性表现很难和原来疾病的症伏相区别。例如,由洋地黄引起的心律失常往往很难与疾病本身所引起的心律失常相区别。因此,心律失常可能是抗心律失常药所表现的毒性,也可被错误地解释为抗心律失常药无效 In recent years, cardiovascular new drugs continue to appear clinically in order to improve the efficacy of a wide range of drugs led to a substantial increase in adverse reactions, and even poisoning death. Adverse reactions to this drug occur through drug interactions that alter the drug concentration at the site of action or through changes in drug receptor sensitivity. The importance of cardiovascular drug interactions is dictated by the severity of the hazard to humans from heart disease and the narrow range of therapeutic concentrations of many cardiovascular drugs. Through the interaction, often the original effective dose into the amount of sub-treatment or poisoning and life-threatening. As mentioned above, the consequences of cardiovascular drug interactions are very serious, but not yet fully understood, because the toxicity of drugs is very difficult to distinguish the symptoms of the original disease. For example, arrhythmias caused by digitalis are often difficult to distinguish from arrhythmias caused by the disease itself. Thus, arrhythmias may be toxic to antiarrhythmic drugs and may be misinterpreted as ineffective antiarrhythmic drugs