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目的了解温州地区ＨＰＶ感染与宫颈炎的关系，为防治该病提供依据。方法用多聚酶链反应（ＰＣＲ）检测１２８例慢性宫颈炎及４８例正常宫颈标本组织中的人乳头瘤病毒（ＨＰＶ）ＤＮＡ，并对ＨＰＶ进行１６、１８型别分析。结果慢性宫颈炎组ＨＰＶ检出率为３２．９％（４２／１２８），ＨＰＶ１６、１８及双重感染（１６＋１８）各占其中的５４％（２３／４８）、１１．９％（５／２４）、１１．９％（５／２４），对照组．ＨＰＶ的检出率为６．３％（３／４８）。两组ＨＰＶ阳性检出率有显著性差异（Ｐ＜０．０５）。结论ＨＰＶ感染，尤其ＨＰＶＩ６感染与慢性宫颈炎相关，但与年龄大小无关。
Objective To understand the relationship between HPV infection and cervicitis in Wenzhou area and provide evidence for the prevention and treatment of this disease. Methods Human papillomavirus (HPV) DNA in 128 cases of chronic cervicitis and 48 cases of normal cervix was detected by polymerase chain reaction (PCR), and HPV types 16 and 18 were analyzed. Results The positive rate of HPV was 32.9% (42/128) in chronic cervicitis group, 54% (23/48) and 11.9% (5/24) in HPV16,18 and double infection (16 + 18) , 11.9% (5/24), control group. The detection rate of HPV was 6.3% (3/48). The positive rate of HPV in both groups was significantly different (P <0.05). Conclusion HPV infection, especially HPVI6 infection, is associated with chronic cervicitis but not with age.