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目的观察消癌平注射液联合SOX方案治疗晚期胃癌的疗效。方法选取2012年5月~2014年5月我院收治的晚期胃癌患者46例,将其随机分为联合治疗组与单纯化疗组,各23例。单纯化疗组予SOX方案化疗(奥沙利铂+替吉奥),联合治疗组在予以SOX方案化疗的同时,给予联合消癌平注射液60 ml/d,连续治疗7天。治疗至少2周后评价疗效。结果联合治疗组总有效率为52.2%,单纯化疗组总有效率为47.8%,组间比较,差异无统计学意义(P>0.05);联合治疗组白细胞减少、功能状态(KPS)评分,与单纯化疗组比较,差异有统计学意义(P<0.05)。而在对血小板和血红蛋白的影响、消化道的不良反应上,两组比较,差异无统计学意义(P>0.05)。结论消癌平注射液联合SOX方案治疗晚期胃癌,疗效显著,可明显提高生活质量,改善KPS评分,为后继治疗奠定良好基础,值得临床推广应用。
Objective To observe the curative effect of Xiao-Jin-Ping Injection combined with SOX regimen in the treatment of advanced gastric cancer. Methods Forty-six patients with advanced gastric cancer admitted to our hospital from May 2012 to May 2014 were randomly divided into combined therapy group and chemotherapy alone group, with 23 cases in each group. Simple chemotherapy group to SOX program chemotherapy (oxaliplatin + for Gio), the combined treatment group was given SOX regimen chemotherapy at the same time, given combined Xiao Jinping injection 60 ml / d, continuous treatment for 7 days. After treatment for at least 2 weeks to evaluate the efficacy. Results The total effective rate was 52.2% in the combined treatment group and 47.8% in the pure chemotherapy group. There was no significant difference between the two groups (P> 0.05). The leukopenia and KPS scores in the combined treatment group were significantly different from those in the combined treatment group Compared with chemotherapy group, the difference was statistically significant (P <0.05). However, there was no significant difference between the two groups in the effect on platelets and hemoglobin, adverse reactions of digestive tract (P> 0.05). Conclusion Xiaojiaoping injection combined with SOX regimen in the treatment of advanced gastric cancer has significant curative effect, which can significantly improve the quality of life and improve the KPS score, which lays a good foundation for subsequent treatment and deserves clinical application.