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目的:观察流行性腮腺炎、麻疹、风疹联合疫苗免疫的效果。方法:选择8月龄接种麻疹疫苗、18月龄时接种1剂MMR,无腮腺炎疫苗史与风疹疫苗史儿童100例,行MMR免疫,在免疫前后采集手指末梢血0.2ml,对麻疹IgG抗体、风疹HI抗体、腮腺炎血凝抑制抗体进行检测。结果:在行MMR免疫前,麻疹IgG抗体与风疹HI抗体的阳性率达100%,腮腺炎HI抗体阳性率为59%。行MMR免疫后,麻疹IgG抗体阳性率仍然为100%。几何平均滴度为1:2653,相较于免疫前,≥4倍增长率为15.4%;风疹HI抗体的阳性率为100%,GMT为1:612.7,相较于免疫前,≥4倍,增长率为51.2%;腮腺炎HI抗体阳性率为97%,GMT为1:33.5,相较于免疫前,≥4倍增长率为71.2%。结论:MMR免疫效果佳,有利于对风疹、麻疹、风疹综合征消除,同时对腮腺炎进行控制,应在接种麻疹疫苗基础上,对免疫策略进行调整,从而采取MMR接种方案。
Objective: To observe the effect of mumps, measles and rubella combined vaccine immunization. Methods: Eighty-month-old measles vaccinees, one MMR vaccine at 18 months of age, 100 children without history of mumps vaccine and history of rubella vaccine were immunized with MMR. Peripheral blood samples were collected before and after immunization with 0.2ml of measles IgG antibody , Rubella HI antibody, mumps hemagglutination inhibition antibody. Results: Before MMR immunization, the positive rate of measles IgG and rubella HI antibody was 100%, and the positive rate of mumps HI antibody was 59%. After MMR immunization, the positive rate of measles IgG antibody was still 100%. The geometric mean titer was 1: 2653, which was 15.4% higher than that before immunization. The positive rate of rubella HI antibody was 100%, the GMT was 1: 612.7, The rate of increase was 51.2%. The positive rate of HI antibody of mumps was 97% and the GMT was 1: 33.5, which was 71.2% higher than that before immunization. CONCLUSION: MMR is effective in immunization and is helpful to eliminate rubella, measles and rubella syndromes and control mumps. MMR vaccination program should be adopted after immunization strategy is adjusted on the basis of measles vaccine.