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全反式维甲酸(ATRA)治疗急性早幼粒细胞性白血病(APL)完全缓解率高达86%。但约1/3的患者在治疗过程中出现高白细胞综合征,导致部分患者早期死亡或因不能耐受而中断治疗。为预防此综合征的发生,根据ATRA诱导分化治疗APL过程中白细胞的动态变化规律,我们在早期预防性应用相对较小剂量的联合化疗,取得了较满意的效果,报告如下。
All-trans retinoic acid (ATRA) treatment of acute promyelocytic leukemia (APL) complete remission rate of up to 86%. However, about one-third of patients develop high leukocyte syndrome during the course of treatment, leading to early death of some patients or interruption of treatment due to intolerance. In order to prevent the occurrence of this syndrome, according to the dynamic changes of leukocytes in the process of APL-induced differentiation and treatment of APL, we used relatively small doses of combination chemotherapy in the early stage and achieved satisfactory results. The report is as follows.