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目的：研究医院住院患者医院感染病原菌变化及耐药性趋势，为临床更合理使用抗菌药物提供参考依据。方法通过回顾性资料分析方法，对某医院2010-2012年临床分离的病原菌及其耐药性进行了统计分析。结果该医院在2010-2012年期间临床分离的病原菌种类居前五位的分别是凝固酶阴性葡萄球菌、大肠埃希菌、白色念珠菌、铜绿假单胞菌和肺炎克雷伯菌。金黄色葡萄球菌和凝固酶阴性葡萄球菌对青霉素、克林霉素等均呈高耐药性。鲍曼不动杆菌和铜绿假单胞菌对多粘菌素B、妥布霉素、亚胺培南均敏感，大肠埃希菌和肺炎克雷伯菌对碳青霉烯类抗菌药物均敏感。白色念珠菌对抗菌药物的耐药率均低于20％。结论本次调查发现，医院感染病原菌以革兰阴性菌为主，普遍对青霉素类耐药，应重视病原菌及其耐药性监测。“,”Objective To analyze the change of pathogens distribution and drug resistance trends of inpatients,so as to provide reference for more rational use of antimicrobial drugs in clinical. Methods Constituent ratio and drug resistance rate of clinical isolates of pathogens were analyzed by retrospective data analysis. Results During year 2010-2012,coag-ulase-negative Staphylococci( CNS),Escherichia coli( ECO),Candida albicans,Pseudomonas aeruginosa( PAE)and Klebsiella pneumoniae( KPN)were the top five species of pathogens. The Staphylococcus aureus( SAU)and CNS showed a high resistance to Penicillin,Clindamycin,etc. Acinetobacter baumannii( ABA)and PAE were sensitive to Polymyxin B, Tobramycin and Imipenem. The resistance rate of Candida albicans to antimicrobial drugs was less than 20%. Conclusion The Gram-negative bacteria are the main nosocomial infection pathogens,which are generally resistant to Penicillin. We should pay more attention to pathogens and their drug resistance surveillance.