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目的 :分析反复附睾或睾丸取精进行卵胞质内单精子注射治疗的妊娠结局。 方法 :收集 2 0 0 1年 1月～2 0 0 2年 12月进行 2周期以上附睾或睾丸取精进行卵胞质内单精子注射治疗的无精子症病人 31例 (共 4 3个周期 ) ,对取精情况及受精、种植和妊娠结局进行总结。 结果 :2 4例病人顺利从附睾取精 ,7例病人从睾丸取精 ,无 1例出现感染、血肿或局部的功能障碍。与第 1周期附睾或睾丸取精 15 4例 (共 15 4个周期 )的受精率、种植率和临床妊娠率比较 ,结果分别是 78.39%与 73.6 4 % ,19.6 8%与 18.38%和 34.88%与 37.91% ,差异无显著性 (P >0 .0 5 )。 结论 :无精子症病人进行反复附睾或睾丸取精 ,是安全和可耐受的 ,其妊娠结局与第 1周期比较无统计学差异。
OBJECTIVE: To analyze the pregnancy outcomes of intracytoplasmic sperm injection with repeated epididymal or testicular sperm retrieval. Methods: Thirty-one patients (43 cycles) with azoospermia who underwent intracytoplasmic spermicidal injection more than 2 weeks from January 2001 to December 2002 were enrolled in this study. Fetal de-fertilization and fertilization, planting and pregnancy outcomes are summarized. RESULTS: Twenty-four patients successfully took the testicles from the epididymis and seven patients took testicles from the testes. None of the patients had infection, hematoma or local dysfunction. The results of fertilization rate, implantation rate and clinical pregnancy rate were 78.39%, 73.6 4%, 19.68%, 18.38% and 34.88% respectively compared with 15 cases (15 4 cycles) of epididymal or testicular sperm in the first cycle. And 37.91%, the difference was not significant (P> 0.05). Conclusion: Azoospermia in patients with repeated epididymal or testicular sperm retrieval is safe and tolerable, and its pregnancy outcome compared with the first cycle no significant difference.