A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle celIs(VSMC) vegetation activities were evaluated by the 3-(4,5-dimethylthlazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method with tetrandrine as a positive contrast drug.The structures of the compounds were confirmed by 1H NMR,13C NMR and electrospray ionization mass spectrometry(ESI-MS).Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relationships(SAR) were discussed in order to investigate the essential structures required for their bioactivities.