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药物不良反应(ADR)越来越多也越来越严重,近几年有关这方面的报道亦渐增多.儿童在药代动力学方面与成人有很大差异,为了保障用药的安全性我科从1986年5月开始以科室为单位,进行长达6年的临床ADR监测工作.现将结果报道如下.1 资料与方法监测对象为1986年5月～1992年5月间因ADR入我院或住院期间发生ADR的患儿,采用医院集中监测法,由专人收集、汇总.ADR评估参照karch和lasagna判断标准:①不良反应是在用药后还是同时发生;②是否符合该种药物的ADR类型;③停药后是否有所改善;④重新使用是否重新出现和需再次治疗;⑤反应能否用已知病的特征和其它治疗解释.
Drug adverse reactions (ADR) more and more serious, more and more reports have been reported in recent years.Children in pharmacokinetics with adults are very different, in order to protect the safety of medication, our department From May 1986 to department as a unit, up to 6 years of clinical ADR monitoring work.The results are reported below.1 Data and Methods The monitoring object for the May 1986 ~ May 1992 due to ADR into our hospital Or hospitalized ADR occurred in children, using hospital centralized monitoring method, collected by hand, summary .ADR assessment refer to karch and lasagna criteria: ① adverse reactions in the medication or at the same time; ② whether the type of drug ADR ; ③ whether after stopping the improvement; ④ re-use and re-emergence of the need to re-treatment; ⑤ response to the characteristics of known diseases and other treatment explained.