利用活化了的氨基酸酯,通过烷基化反应合成α-氨基酸是近年来使用的简便方法。特别是以苯甲醛与简单的氨基酸酯反应生成的Schiff碱为底物,用固-液相转移催化烷基化反应合成a-氨基酸,不仅条件温和,而且操作简便,原料易得,选择性好。我们采用上述方法成功地合成了α-甲基 The use of activated amino acid esters to synthesize a-amino acids by alkylation is a convenient method used in recent years. In particular, the reaction of benzaldehyde with a simple amino acid ester Schiff base as a substrate, solid-liquid phase catalytic reaction catalyzed alkylation of a-amino acids, not only mild conditions, but also easy to operate, easy to get raw materials, good selectivity . We successfully synthesized α-methyl using the above method