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远在17世纪,Richard Mortan就记载了糖尿病在某些家族中有多发现象。本世纪初Naunyn在所调查的398例糖尿病病例中,发现67例(17％)有家族史,并指出有所谓“早发”现象,即子代糖尿病发病年龄早于亲代。此后Pineus和White又对青年糖尿病患者的亲代是否患有糖尿病进行了调查,发现实际观察值和按照单纯隐性遗传算出的期待值相当一致,据此提出了糖尿病的常染色体隐性遗传学说。该学说被广泛支持,尤其得到了Steinberg的强烈支持。
As far back as the 17th century, Richard Mortan documented the high incidence of diabetes in some families. At the turn of the century, Naunyn found a family history of 67 (17%) of the 398 diabetes cases investigated, noting that there was a so-called “premature” phenomenon, in which offspring diabetes onset was earlier than in the parent. Since then, Pineus and White investigated the incidence of diabetes among the parents of young diabetic patients and found that the actual observations were in good agreement with the expected values based on the simple recessive inheritance. Therefore, the autosomal recessive inheritance theory of diabetes was proposed. The doctrine is widely supported, especially with Steinberg’s strong support.