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目的 研究 P53、P-糖蛋白在肿瘤中的表达与肿瘤预后关系。方法 应用经改良的 SP免疫组化方法 ,统计学分析采用 X2检验。结果 P53蛋白阳性率 52 .63% ;P-糖蛋白阳性率为 51 .32 %。 P53蛋白和 P-糖蛋白阳性表达与肿瘤细胞的分化程度和临床分期无显著性差异 (P>0 .0 5) ,但两者之间存在密切相关 (P<0 .0 1 )。 结论 P53基因对P-糖蛋白的阳性表达有关 ,表明 P53蛋白阳性的肿瘤细胞对某些化疗药物具有较低的敏感性 ,P53蛋白阳性表达和 P-糖蛋白阳性表达是病人预后较差的主要原因之一。
Objective To study the relationship between the expression of P53 and P-glycoprotein in tumor and the prognosis of tumor. Methods The improved SP immunohistochemical method was used. Statistical analysis was performed using X2 test. Results The positive rate of P53 protein was 52.63%; the positive rate of P-glycoprotein was 51.32%. The positive expression of P53 protein and P-glycoprotein was not significantly different from the tumor cell differentiation and clinical stages (P>0.05), but there was a close correlation between the two (P<0.01). Conclusion The positive expression of P53 is related to P-glycoprotein, indicating that P53-positive tumor cells have low sensitivity to certain chemotherapeutic drugs. Positive expression of P53 protein and positive expression of P-glycoprotein are the main causes of poor prognosis of patients. one of the reasons.