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目的观察吉西他滨联合奥沙利铂方案治疗晚期胆囊癌和胆管癌临床疗效和毒副作用。方法 16例晚期胆囊癌和胆管癌患者,应用吉西他滨联合奥沙利铂方案化疗,即吉西他滨l 000 mg/m2,第1、第8天应用,奥沙利铂100mg/m2,第1天。每21天重复,直至出现不可耐受的副作用或肿瘤进展。结果 16例均可以进行疗效评价,CR 1例,PR 6例,SD 6例,PD3例,总有效率43.7%。中位生存期为12.8个月。不良反应主要为骨髓抑制、外周神经炎等。结论吉西他滨联合奥沙利铂方案治疗晚期胆囊癌和胆管癌近期疗效较好,不良反应有可以耐受性。可作为晚期胆囊癌和胆管癌的治疗选择。
Objective To observe the clinical efficacy and side effects of gemcitabine combined with oxaliplatin in the treatment of advanced gallbladder cancer and cholangiocarcinoma. Methods Sixteen patients with advanced gallbladder cancer and cholangiocarcinoma were treated with gemcitabine combined with oxaliplatin regimen, that is, gemcitabine 1000 mg / m2. The first and the eighth day of application were given oxaliplatin 100 mg / m2 on the first day. Repeated every 21 days until intolerable side effects or tumor progression. Results All the 16 cases could be evaluated. There were 1 case of CR, 6 cases of PR, 6 cases of SD and 3 cases of PD, the total effective rate was 43.7%. The median survival was 12.8 months. Adverse reactions mainly bone marrow suppression, peripheral neuritis and so on. Conclusion The combination of gemcitabine and oxaliplatin in the treatment of advanced gallbladder cancer and cholangiocarcinoma has good curative effect in the near future and the adverse reaction is tolerable. Can be used as the treatment of advanced gallbladder cancer and cholangiocarcinoma.