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曾报道凤仙花中含有抗变态反应及抗瘙痒的成分指甲花醌(1),本次探讨了与其相关的包括新化合物(5)的源于凤仙花中的化合物5～7及合成的2～4萘醌类对瘙痒及特应性皮炎的效果。 方法:按照曾报道的方法以化合物48/80(COM)刺激引起小鼠的搔抓行为,探讨抗瘙痒活性。在试验前24h经口给予化合物2～7(10mg/kg)。对于显示活性的化合物进一
It has been reported that Impatiens balsamina contains antihypersensitivity and antipruritic components of henna (1). This time, it discusses related compounds 5 to 7 derived from impatiens including new compounds (5) and their synthesis. The effect of 2 to 4 naphthoquinones on itching and atopic dermatitis. METHODS: The scratching behavior of mice induced by compound 48/80 (COM) stimulation was investigated according to a previously reported method to investigate antipruritic activity. Compounds 2-7 (10 mg/kg) were orally administered 24 h before the test. For compounds that show activity