目的　短期观察氯沙坦对早期糖尿病肾病 (DN)患者尿蛋白的排泄和肾功能的影响。方法　 2 2例早期 DN患者在抗糖尿病常规治疗的基础上加用氯沙坦 (5 0 mg/d) ,短期观察 10～ 12周。结果　病人治疗前后血糖均无明显改变 (P>0 .0 5 )。尿微量白蛋白下降 ,肌酐清除率 (Ccr)也明显降低 (P <0 .0 1) ,但尿素氮 (BU N)、肌酐 (Cr)无明显改变。结论　早期 DN的治疗中使用氯沙坦 ,可以降低尿蛋白排泄 ,阻止肾脏损害的发展 ,保护肾功能。 Objective To observe the effect of losartan on urinary protein excretion and renal function in patients with early diabetic nephropathy (DN) in short term. Methods Twenty-two patients with early-stage DN were treated with losartan (50 mg / d) on the basis of conventional anti-diabetic therapy and were observed for 10-12 weeks in short term. Results There was no significant change in blood glucose before and after treatment (P> 0.05). Microalbuminuria and creatinine clearance (Ccr) also decreased significantly (P <0.01), but no changes were found in BU N and Cr. Conclusion Losartan treatment with early losartan can reduce urinary protein excretion, prevent the development of renal damage and protect renal function.