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早在1942年Kilnefelter’s首次描述报道了该综合征的临床特征,即先天性睾丸曲细精管发育不全,小睾丸,男性乳房发育,男性性功能低下和男性不育,随后,国内外文献屡见有关Klinefelter’s综合征(以下称克氏征)的报道。然而,国内文献未见有关克氏征与恶性肿瘤的报道,尤其与伴发原发性(纵隔生殖细胞肿瘤的系统描述,本文就此问题作一综述。一、克氏征的发病率在男性生殖腺发育不良,和无生殖能力患者中克氏征占30％,凌丽华等报道38例性功能不全患者中克氏征14例(占36.8％),在
As early as 1942 Kilnefelter’s first report described the clinical features of the syndrome, namely, congenital testicular seminiferous tubule dysplasia, small testicles, male breast development, male sexual dysfunction and male infertility, followed by frequent domestic and foreign literature Klinefelter’s syndrome (hereinafter referred to as Kirschner Sign) reports. However, there are no reports of Kirschner’s disease and malignant tumors in the domestic literature, especially with the systematic description of the primary mediastinal germ cell tumors, which is reviewed in this paper.I, the incidence of Crohn’s disease in the male gonads Dysplasia, and non-reproductive capacity in patients with Kirschs lent 30%, Ling Li et al reported 38 cases of dysfunction in patients with Kirschner sign 14 cases (36.8%), in