论文部分内容阅读
维甲酸类是一类天然的或合成的具有维生素A(Vit A)活性的视黄醇衍生物。Vit A是正常上皮增殖和分化所必需的,但当用于治疗皮肤角化病时其副作用大,治疗剂量即易引起急性中毒。为了寻找毒性较低的此类药物,过去几年中合成了1500多种维甲酸类化合物,有治疗意义的第一代维甲酸是异维甲酸(Isotretinoin),对严重的结节性和团块性痤疮疗效较好,首次使该病获得长期缓解。第二代维甲酸的代表药物是依维甲酯(Etretinate),是严重牛皮癣治疗中的一大突破,
Retinoids are a family of natural or synthetic retinol derivatives with vitamin A activity. Vit A is required for normal epithelial proliferation and differentiation, but its side effects are high when used to treat keratosis of the skin, which can cause acute poisoning at therapeutic doses. In search of these less toxic drugs, more than 1,500 retinoids have been synthesized over the past few years. The first-generation Tretinoin that is of therapeutic interest is Isotretinoin, which is responsible for severe nodularity and mass Acne is effective, for the first time the disease was long-term relief. The second generation of retinoic acid is represented by drug Etretinate (Etretinate), is a major breakthrough in the treatment of severe psoriasis,