论文部分内容阅读
肿瘤异质性是近年来恶性肿瘤的研究热点,已成为解决肿瘤转移、复发和耐药的突破口。本文就肿瘤遗传异质性最新研究进展、卵巢癌肿瘤异质性的分子机制以及异质性的系统进化和量化进行详细的描述,并对肿瘤异质性量化的临床意义,特别是在当前“精准医学”时代如何利用这种异质性的特点改进肿瘤靶向治疗的效果进行了分析和思考。现综述如下。
Tumor heterogeneity is a hot research topic of malignant tumors in recent years and it has become a breakthrough to solve the problem of tumor metastasis, relapse and drug resistance. In this paper, the latest research progress of tumor genetic heterogeneity, molecular mechanisms of heterogeneity of ovarian cancer and the systematic evolution and quantification of heterogeneity are described in detail, and the clinical significance of quantification of heterogeneity of tumors, especially in the current “Precision Medicine ” era how to use the characteristics of this heterogeneity to improve the efficacy of tumor targeted therapy were analyzed and pondered. Are summarized below.