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信号通路是研究肿瘤发生发展、预防及治疗的重要领域之一,现已证实MAPK和PI3K等通路是肿瘤发生发展的重要信号通路,甲状腺激素(TH)及其受体(TR)可以影响这些通路起到抑制癌细胞生长和转移的作用,并逐渐成为研究的热点。而研究发现多种肿瘤存在TR基因突变现象,TR基因突变影响了TH/TR调解下游通路的功能,并成为下游原癌基因激活的诱因。近年研究发现了TH/TR介导的β-连环蛋白(β-catenin)降解机制,不仅丰富了它们在肿瘤发生发展中的作用,并进一步为突变受体对下游原癌基因的持续激活提供了理论依据。相信随着对其下游通路研究的进一步深入,最终会指导临床,为肿瘤预防和分子靶基因治疗提供新的理论依据。
The signal pathway is one of the most important fields to study the development, prevention and treatment of tumors. It has been confirmed that MAPK and PI3K are important signaling pathways for tumorigenesis. Thyroid hormone (TH) and its receptor (TR) can affect these pathways Play a role in inhibiting the growth and metastasis of cancer cells, and gradually become a research hot spot. The study found that a variety of tumors exist TR gene mutations, TR gene mutations affect the function of TH / TR mediate downstream pathway and become a downstream incentive for protooncogene activation. Recent studies have found that TH / TR-mediated mechanism of β-catenin degradation not only enriches their role in tumorigenesis, but also provides further evidence for the continued activation of downstream protooncogenes by mutated receptors Theoretical basis. Believe that with the further study of its downstream access, will eventually guide the clinical, provide a new theoretical basis for cancer prevention and molecular target gene therapy.