【摘 要】
：
Objective To investigate whether two kinds of in vitro prepared advanced glycation end products (AGEs), Glu-BSA and Gal-BSA, could change oxidation stress and a
【机 构】
：
Institute of Medicinal Biotechnology
【基金项目】
：
国家自然科学基金;This work was supported by a grant from the National Key Basic Research Development Program Foundation of China
论文部分内容阅读
Objective To investigate whether two kinds of in vitro prepared advanced glycation end products (AGEs), Glu-BSA and Gal-BSA, could change oxidation stress and anti-oxidation abilities in astrocytes, and thus might contribute to brain injury. Methods Changes of GSH, MDA, SOD,MAO-B, nitric oxide were measured after AGEs treatment. Results Both 0.1 g/L Glu-BSA and Gal-BSA could slightly decrease GSH level, while 1 g/L of them significantly decreased GSH level by 35% and 43% respectively. The MDA levels of both 1 g/L AGEs treated groups (306±13 and 346±22) were higher than that of the normal group (189±18), which could be inhibited by free radical scavenger NAC. The SOD activities of both 1 g/L AGEs treated groups (67.0±5.2 and 74.0±11.0)were lower than that of the normal group (85.2±8.0). Both 0.1 g/L AGEs could slightly increase the activity of MAO-B, while 1 g/L of them could increase MAO-B activity by 1.5 and 1.7 folds respectively. Both AGEs stimulation could produce NO level by 1.7 and 2 folds respectively.Conclusion Enhanced levels of astrocytic oxidation stress and decrease of antioxidation abilities may contribute to, at least partially, the detrimental effects of AGEs in neuronal disorders and aging brain.
其他文献
A scanning electron microscope was used to observe the structures of the setae on the surface of a dung beetle Copris ochus, Motschulsky. There are lots of seta
本文首先从理论上分析了分层次教学的问题,然后重点介绍了高职院校分层次教学的实践及测评,最后讨论了英语分层次教学的实验分析方法及对CET(大学英语等级考试)成绩影响分析
This paper deals with the topic of RF plasma sources and their application in highpower neutral beam heating systems for nuclear fusion devices. RF sources repr
在依据Dirac约束规范理论和作推广后的条件下,导出了规范生成元,推导出了1+1维O(3)非线性σ模型的一般条件(β≠0)下的BRST变换,给出了其BRST变换与Dirac规范变换的等价关系,
利用随机过程的谱展开理论以及Hudson等人的裂纹介质模型构造一种裂纹数密度是空间平稳随机过程的随机介质模型.这个模型可以将裂纹的微观参数(裂纹数密度)与裂纹介质的宏观
This paper studied the conditions such that an n-dimensional complete space-like submanifold M with a parallel mean curvature vector field in an indefinite spac
The crystallization properties and morphology structure of the cationic dyeable polypropylene fibers which were produced by the blending spinning method were st
Many animals have a magic ability to move or hold on ceilings and walls because of the design of their adhesive pads.The experiments were carried out to study t
Using the relationship between the resistance, capacitance and current in Hopfield neural network, and the properties of sigmoid function, this paper gives the
To enhance the robustness of video transmission over noisy channels, this paper presents a multiple description video coding algorithm based on chessboardinterp