论文部分内容阅读
研究目的:评估急性期脑梗死患者运动功能障碍患者的脑区时间变异性改变及其临床预后相关性;材料与方法:收集20位急性脑梗死患者梗死后1周及2周内的两次静息态功能磁共振数据以及患者三个月后的运动功能评估量表,运用复旦冯建峰团队的时间变异性程序计算脑区的时间变异性,并采用配对T检验比较患者状态的改变,采用Pearson相关评价时间变异性改变在临床运动评估的能力。结果:对比第一次扫描,脑梗死患者发生改变的脑区主要在运动脑区,额叶脑区及皮层下脑区,患侧中央前回的变异性改变程度与临床量表的改变程度正相关。结论:功能磁共振及时间变异性指标是有效的评价卒中患者运动功能改变及恢复的工具,皮下脑区的改变可能与代偿机制有关。
Objective: To evaluate the time-dependent changes of brain regions in patients with motor dysfunction in patients with acute cerebral infarction and their clinical prognostic significance. MATERIALS AND METHODS: Twenty patients with acute cerebral infarction were collected at 1 week and 2 weeks after infarction FMRI and motor function evaluation scale of patients after three months, the temporal variability of brain area was calculated by the time variability program of Fudan Feng Jianfeng team, and the changes of patients’ status were compared by paired T test. Pearson correlation Evaluate the ability of time variability to change in clinical exercise assessment. Results: Compared with the first scan, the changes of brain areas in patients with cerebral infarction mainly in the motor brain area, frontal cortex and subcortical brain areas, and the degree of change in the variability of the central ipsilateral central frontal gyrus positively correlated with the degree of change in the clinical scale . Conclusion: The indexes of functional magnetic resonance and time variability are effective tools to evaluate the change of motor function and recovery in stroke patients. The change of subcutaneous brain area may be related to the compensatory mechanism.