目的研究Helicobacter pylori菌株本身的毒力差异是否与H.pylori菌株对甲硝唑的敏感性有关。方法 用E-test方法检测109株H.pylori菌株对甲硝唑的敏感性;PCR检测H.pylori菌株不同的vacA基因亚型、cagA、iceA和babA2基因型。结果 云南地区甲硝唑耐药率为67.89％;vacA、cagA、iceAl、babA2基因的各种基因亚型和基因型在H.pylori菌株甲硝唑耐药率上无显著性差异。结论 H.pylori菌株本身的毒力差异与H.pylori菌株对甲硝唑的敏感性无关。 Objective To study whether the virulence difference of Helicobacter pylori strain itself is related to the sensitivity of H. pylori strain to metronidazole. Methods The sensitivity of 109 strains of H.pylori to metronidazole was tested by E-test. The genotypes of vacA, cagA, iceA and babA2 of H.pylori strains were detected by PCR. Results The metronidazole resistance rate in Yunnan was 67.89%. The genotypes of vacA, cagA, iceAl and babA2 genes showed no significant difference in the metronidazole resistance of H.pylori strains. Conclusion The virulence differences of H.pylori strains are not related to the sensitivity of H.pylori strains to metronidazole.