亲代谢型谷氨酸受体 (metabotropicglutamaterecep tors,mGluRs)是一类与G蛋白偶联的调节离子通道和第二信使生成酶的新型谷氨酸受体 ,在基底神经节 (basalganglia ,BG)分布非常广泛。分布于BG的各亚型mGluRs受体能够调节多巴胺 (dopamine ,DA)和谷氨酸 (glutamate,Glu)的释放 ,其调节效应与脑区、受体亚型以及药物浓度等相关。mGluRs多样性的发现及其在调节BG神经传递中的作用为治疗PD提供了有益的靶标 Metabotropic glutamate receptors (mGluRs) are a class of novel glutamate receptors that regulate the ion channels and second messenger-generating enzymes that are coupled to the G protein. In the basal ganglia (BG) distribution Very extensive. The subtypes of mGluRs distributed in BG regulate the release of dopamine (DA) and glutamate (Glu), and their regulatory effects are related to brain regions, receptor subtypes and drug concentration. The discovery of mGluRs diversity and its role in the regulation of BG neurotransmission provide a useful target for the treatment of PD