论文部分内容阅读
目的 :探讨肌肉损伤后MRI的信号变化与病理改变之间的关系.方法 :采用 14只灰兔建立肌肉损伤的动物模型 ,在损伤后多次行MRI检查并分 8次处死兔子进行光镜和电镜检查与MRI对照.结果 :MRI表现 ,肌肉损伤后在T1WI表现高信号影 ,可维持 40d以上 ;在T2WI上 ,损伤后表现为高信号影 ,在 44d时基本恢复正常.病理改变 :光镜下主要表现为出血、水肿、肌肉变性坏死及炎性细胞浸润 ;3d时变化最为明显.电镜主要表现为肌纤维变性水肿 ,线粒体变大 ,肌浆网扩张 ,肌纤维间可见高电子密度颗粒 ,电镜下病理改变的峰值在 5~ 7d ,但一些异常改变可持续 40d以上.结论 :对肌肉损伤MRI是最好的检查手段 ,它能反映某些病理变化.“,”Objective:To explore the signal changes of posttraumatic muscles and to study the relationship between pathological changes and MRI of muscle injury.Methods:Muscle injury models on 14 rabbits were set up and imaged with MRI several times after trauma.Randomly selected eight rabbits were sacrificed to obtain injured muscle tissue samples for light microscopic and eletron microscopic studies to compare with MRI.Results:The injured muscls showed high signal of T1WI and were kept more than 40 days.The pathological changes were hemorrhage,edema,degeneration,muscular necrosis,infiltration of inflammatotry cells.They are obvious on the 3rd day.The ultrastructlar changes were musclar fiber edema,mitochondrion enlargement,sarcoplasmic reticulum dilation and many high electronic density granules among muscular fibers.The peak of ultrastructural changes is during the 5th to 7th day and some abnormal changes are kept after 40 days.Conclusion:MRI is the best choice for muscle injury because of its close relationship with ultrastructural changes.