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人脐带间充质干细胞是一种从人脐带间质组织中分离出来的全能干细胞,具有自我更新、免疫缺陷和多向分化潜能。新近研究表明,人脐带间充质干细胞在体内微环境及体外细胞因子的作用下不仅能够分化为胰岛样细胞,而且具有一定的β细胞分泌功能,能够降低血糖,克服了胰岛移植治疗糖尿病所面临的供体细胞缺乏和免疫排斥反应问题,从而有望为临床糖尿病细胞治疗开辟了一条新的途径。
Human umbilical cord mesenchymal stem cells are pluripotent stem cells isolated from human umbilical cord stromal tissue and have the potential for self-renewal, immunodeficiency and multidirectional differentiation. Recent studies show that human umbilical cord mesenchymal stem cells can not only differentiate into islet-like cells under the action of microenvironment and cytokines in vitro, but also have certain β-cell secretory functions, which can lower blood glucose and overcome the problems of islet transplantation in the treatment of diabetes Lack of donor cells and immune rejection, which is expected to open a new avenue for the clinical treatment of diabetic cells.